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综合介绍 General Introduction 孙乐明博士，西北工业大学生命学院长聘副教授，硕士生导师，院长助理。2017年获得美国俄亥俄州立大学生物医学工程专业博士学位。近年来主要围绕金属离子配位驱动的多肽和蛋白质等生物分子自组装的基础和应用研究，重点开展了特殊环境生物耐受机制及其仿生学应用、多肽纳米探针及其用于疾病检测、新型多肽药物研发等科学研究工作，取得了一系列创新性研究成果，承担了国家自然科学基金和陕西省自然科学基金等科研项目10余项，累计发表SCI学术论文50余篇，担任Asian Journal of Pharmaceutical Sciences和Chinese Chemical Letters等期刊青年编委，申请和授权国家发明专利6项，指导学生获得了挑战杯国赛一等奖1项。 个人相册

教育教学

科学研究 Scientific Research 研究方向1. 多肽自组装2. 疾病诊断和治疗3. 基于多肽的光电材料4. 特殊环境生物耐受机制及其仿生应用

荣誉获奖

学术成果 Academic Achievements 先后主持国家自然科学基金、陕西省自然科学基金、广东省基础与应用基础研究基金、重庆市自然科学基金等课题10余项。在Signal Transduction and Targeted Therapy、Drug Resistance Updates、Chemical Engineering Journal、ACS AMI、Chinese Chemical Letters等国内外重要刊物发表SCI论文50余篇。L. Sun, H. Liu, Y. Ye, Y. Lei, R. Islam, S. Tan, R. Tong, Y. Miao*, L. Cai*. Smart nanoparticles for cancer therapy, Signal Transduction and Targeted Therapy, 2023, 8, 418.Y. Wang, Y. Lei, J. Wang, H. Yang*, L. Sun*. Tetrapeptide self-assembled multicolor fluorecent nanoparticles for bioimaging applications, Chinese Chemical Letters, 2023, 34, 107915.J. Xuan, W. Feng, J. Wang, R. Wang, B. Zhang, L. Bo, Z. Chen*, H. Yang*, L. Sun*. Antimicrobial peptides for combating drug-resistant bacterial infections, Drug Resistance Updates, 2023, 68, 100954.L. Sun*, Y. Lei, Y. Wang, D. Liu. Blood-based Alzheimer’s disease diagnosis using fluorescent peptide nanoparticle arrays, Chinese Chemical Letters, 2022, 33, 1946-1950.W. Lin, Y. Yang, Y. Lei, F. An, L. Sun*, Y. Qin, L. Zhang*. Self-assembly of an antitumor dipeptide induced near-infrared fluorescence and improved stability for theranostic applications, ACS Applied Materials & Interfaces, 2021, 13, 32799-32809.L. Sun*, D. Liu, D. Fu, T. Yue, D. Scharre, L. Zhang*. Fluorescent peptide nanoparticles to detect amyloid-beta aggregation in cerebrospinal fluid and serum for Alzheimer’s disease and progression monitoring, Chemical Engineering Journal, 2021, 405, 126733.D. Liu, D. Fu, L. Zhang, L. Sun*. Detection of amyloid-beta by Fmoc-KLVFF self-assembled fluorescent nanoparticles for Alzheimer’s disease diagnosis, Chinese Chemical Letters, 2021, 32, 1066-1070.D. Fu, D. Liu, L. Zhang, L. Sun*. Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications, Chinese Chemical Letters, 2020, 31, 3195-3199.L. Sun, A. Li, Y. Hu, Y. Li, L. Shang, L. Zhang*. Self-assembled fluorescent and antibacterial GHK-Cu nanoparticles for wound healing applications, Particle & Particle Systems Characterization, 2019, 36(4), 1800420.L. Sun*, Z. Fan, T. Yue, J. Yin, J. Fu, M. Zhang. Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimer’s disease diagnosis, Bio-Design and Manufacturing, 2018, 1(3), 182-194.K. Tao, Z. Fan, L. Sun, P. Makam, Z. Tian, M. Ruegsegger, S. Shaham-Niv, D. Hansford, R. Aizen, Z. Pan, S. Galster, J. Ma, F. Yuan, M. Si, S. Qu, M. Zhang*, E. Gazit*, J. Li*. Quantum confined peptide assemblied with tunable visible to near-infrared spectral range, Nature Communications, 2018, 9(1), 3217.Z. Fan, Y. Chang, C. Cui, L. Sun, H. Wang, Z. Pan*, M. Zhang*. Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy, Nature Communications, 2018, 9(1), 2605.L. Sun*, Y. Hu, L. Zhang*. Recent trends in nanocrystals for pharmaceutical applications, Current Pharmaceutical Design, 2018, 24, 1-9.Y. Wang, L. Yu, X. Kong, L. Sun*. Application of nanodiagnostic in point-of-care tests for infectious diseases, International Journal of Nanomedicine, 2017, 12, 4789-4803.L. Sun, Y. Huang, Z. Bian, J. Petrosino, Z. Fan, Y. Wang, KH. Park, T. Yue, M. Schmidt, S. Galster, J. Ma*, H. Zhu*, M. Zhang*, Sundew-inspired adhesive hydrogels combined with adipose-derived stem cells for wound healing, ACS Applied Materials & Interfaces, 2016, 8(3), 2423-2434.Z. Fan, L. Sun, Y. Huang, Y. Wang, M. Zhang*, Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release, Nature Nanotechnology, 2016, 11(4), 338-394.T. Fan, X. Yu, B. Shen*, L. Sun*. Peptide self-assembled nanostructures for drug delivery applications, Journal of Nanomaterials, 2017, 2017(16), 4562474.T. Yue, X. Jia, J. Petrosino, L. Sun, Z. Fan, J. Fine, R. Davis, S. Galster, J. Kuret, D. Scharre, M. Zhang*. Computational integration of nanoscale physical biomarkers and cognitive assessments for AD diagnosis and prognosis, Science Advances, 2017, 3(7), e1700669.L. Sun, Z. Fan, Y. Wang, Y. Huang, M. Schmidt, M. Zhang*, Tunable synthesis of self-assembled cyclic peptide nanotubes and nanoparticles, Soft Matter, 2015, 11(19), 3822-3832.

科学研究

学术成果

综合介绍