触觉是人类重要的感觉之一。正性触觉刺激可以促进认知发育、舒缓压抑情绪，而一些精神疾病患者往往存在触觉信息加工整合障碍。那么，触觉经历如何调节大脑发育与可塑性，进而调节认知和情绪？触觉与其它感官信息的整合如何影响大脑与行为？单模态或跨模态感觉信息加工整合异常又如何参与应激相关精神障碍的发生发展？ 王晓东课题组结合行为学、活动神经元标记与操控、深度学习等技术，旨在探索跨模态感觉整合障碍在应激相关精神障碍中的作用机制。欢迎本科生、博士后加入我们的团队！！代表性论文：Wu C#, Gong Q#, Xu X, Fang P, Wang C, Yu YJ, Wang XX, Fang SH, Chen WJ, Lou HF, Liu YH, Wang L, Liu YJ, Chen W*, Wang XD* (2022). Disrupted presynaptic nectin1-based neuronal adhesion in the entorhinal-hippocampal circuit contributes to early-life stress-induced memory deficits. Translational Psychiatry 12, 141.Wang C#, Liu H#, Li K#, Wu ZZ, Wu C, Yu JY, Gong Q, Fang P, Wang XX, Duan SM, Wang H, Gu Y, Hu J, Pan BX, Schmidt MV, Liu YJ, Wang XD* (2020). Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis. Nature Communications 11, 6045.Liu YJ*,#, Zhang T#, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD*, Ho MS*, Duan S (2021). The noncanonical role of the protease cathepsin D as a cofilin phosphatase. Cell Research 31, 801-813.Liu YJ*, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS*, Wang XD*, Duan S* (2020). Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD. Science Advances 6, eaba5783.Li JT#, Xie XM#, Yu JY, Sun YX, Liao XM, Wang XX, Su YA, Liu YJ, Schmidt MV, Wang XD*, Si TM* (2017). Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss. Cell Reports 21, 891-900.Wang XX, Li JT, Xie XM, Gu Y, Si TM, Schmidt MV, Wang XD* (2017) Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory. Translational Psychiatry 7, e1228.Yang XD, Liao XM, Uribe-Marino A, Liu R, Xie XM, Jia J, Su YA, Li JT, Schmidt MV, Wang XD*, Si TM* (2015). Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1. Neuropsychopharmacology 40, 1203-1215.Wang XD, Su YA, Avrabos C, Wagner KV, Liebl C, Wolf M, Scharf SH, Hartmann J, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV* (2013). Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nature Neuroscience 16, 706-713.Wang XD*, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV (2011). Forebrain CRF1 modulates early life stress-programmed cognitive deficits. The Journal of Neuroscience 31, 13625-13634.
织梦好，好织梦
