周民 博士 长聘教授 博士生导师 恶性肿瘤预警与干预教育部重点实验室 副主任 国家万人计划科技领军人才 国家级高层次人才 浙江省特聘专家 浙江大学爱丁堡大学联合学院 教授 浙江大学医学院附属第二医院 教授 科技部重点领域创新团队核心成员 现代光学仪器国家重点实验室固定成员 研究领域及方向 活性微藻载药系统 多模态分子影像探针的研发及其临床转化研究 基于纳米材料的药物装载与控制释放研究 新型耐药菌治疗技术研究 新型肿瘤治疗技术的研发及其临床转化研究 生物医学光子学 干细胞示踪 研究课题 国家自然科学基金、 科技部国家重点研发计划等 主要研究成果 在影像医学、生物材料及纳米医学领域，多年主要围绕“分子影像和转化医学”在癌症及感染性疾病诊断及治疗等方向，致力于新型多功能生物材料及小分子药物临床转化研究。设计、制备具有较好临床转化前景的医用材料，并在包括猕猴等大动物水平的多尺度动物模型水平探索其临床转化可行性，做出一系列创新性的、探索性的科研成果。首创性利用活性微藻材料作为载体靶向输送抗肿瘤及抗感染药物，并探索在乳腺癌、结直肠癌等领域的临床转化。研发了集正电子发射断层（PET）影像功能和光热转化功能于一体的生物纳米材料，并将其运用于肿瘤显像以及影像指导下癌症光热治疗等多方面研究。生物纳米材料临床转化可行性研究，包括在肿瘤光声成像、光热治疗与其他治疗方式包括放疗、化疗、免疫治疗、药代动力学及毒理学等联合治疗等多方面研究。大分子药物、蛋白质、多肽以及纳米材料的放射性标记及核医学成像，包括材料的标记、药代动力学、生物组织分布及PET/SPECT影像分析，为药物及靶向生物材料的临床转化提供指导。耐药菌感染疾病药物的医学成像及靶向治疗。干细胞示踪，以多功能纳米材料为介体，通过PET、MRI、光声及光学等多影像方式对干细胞进行长程、靶向、精准示踪。 代表性成果 团队研发了全球第一个角膜炎感染治疗纳米药物，经过医院伦理审批，正在开展人体临床试验，已治愈多位难治性角膜炎感染患者，并收到患者送来的致谢锦旗，为角膜炎患者带来新的希望。 代表性论著 至今在国际重要学术期刊上共发表高质量SCI论文100余篇，总影响因子>600，他引>6000次，单篇引用次数超过200文章5篇，最高单篇他引>600。其中以通讯作者分别在纳米医学、分子影像学、生物材料学、化学等领域国际著名专业期刊 Chem, Matter, Science Advances, Nature Communications, Research, Advanced Materials, ACS Nano, Advanced Science, Nano Today, Advanced Functional Materials, Biomaterials, Small 等杂志上发表50余篇，并有13篇论文选为杂志封面，6篇ESI高被引论文。代表性论文如下: 1. Hua S., ... Zhou M* 'Natural floating biosystem for alcohol-induced diseases'Matter, 2024, in press (IF=18.900)2. Zhong D., ... Zhou M* 'Microalgae-Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression'Advanced Materials, 2024, 202312275 (IF=32.086)3. Hu H, Hua S., ... Zhou M* 'Hybrid biomimetic membrane coated particles-mediated bacterial ferroptosis for acute MRSA pneumonia'ACS Nano, 2023, 17, 11692-117121(IF=18.027)4. Zhand D, He J, ... Zhou M* 'Oral Microalgae-Nano Integrated System against Radiation-Induced Injury'ACS Nano, 2023, 17, 10560-10576(IF=18.027)5. Ren C, Zhong D, ... Zhou M* 'Bioinspired pH-Responsive Microalgal Hydrogels for Oral Insulin Delivery with Both Hypoglycemic and Insulin Sensitizing Effects'ACS Nano, 2023, 17, nn-2023-04897e (IF=18.027) 6. Deng K, Tang T, ... Zhou M* 'A biodegradable, flexible photonic patch for in vivo phototherapyy'Nature Communications, 2023, 14, 3069 (IF=17.694) 7. Zhang D, Zhong D, ... Zhou M* 'Host Defense Peptide Mimicking β-Peptide Polymer Acting as a Dual-Modal Antibacterial Agent by Interfering Quorum Sensing and Killing Individual Bacteria Simultaneously'Research, 2023, 6, 0051 (IF=11.036) 8. Zhang D, Zhong D, ... Zhou M* 'Radiation-assisted strategies provide new perspectives to improve the nanoparticle delivery to tumor'Advanced Drug Delivery Reviewss, 2023, 193, 114642 (IF=17.873) ESI 高被引论文 9. He J, Ye Y, ... Zhou M* 'Visualized Gallium/Lyticase-Integrated Antifungal Strategy for Fungal Keratitis Treatment'Advanced Materials, 2022, 202206437 (IF=32.086) 10. He J, Hua S, ... Zhou M* 'SERS/NIR-II Optical Nanoprobes for Multidimensional Tumor Imaging from Living Subjects, Pathology, and Single Cells and Guided NIR-II Photothermal Therapy'Advanced Functional Materials, 2022, 2208028 (IF=19.924) 11. Zhang D, Zhong D, ... Zhou M* 'Natural oral microcarriers for gut microbiota homeostasis and whole intestinal protection in cancer radiotherapy'Nature Communications, 2022, 13, 1413 (IF=14.919) 12. Hu H, Zhong D, ... Zhou M* 'Quorum Sensing Inhibitor for Chronic Wound Healing by Microalgae-Based Bioactive Hydrogel' Nano Today, 2022, 42, 101368 (IF=18.962)13. Tang Q, Lu B, He J, ... Zhou M*'Thermosensitive Exosomes Hydrogels for Corneal Epithelium and Stroma Regeneration'Biomaterials, 2022, 280, 121320 (IF=15.304)14. Zhong D, Zhang D, ... Zhou M* 'Orally Deliverable Strategy Based on Microalgal Biomass for Intestinal Diseases Treatment'Science Advances, 2021, 7, 9265 (IF=14.957, Cover 封面文章)15. Zhong D, Chen Y, ... Zhou M*'Aggregation-Induced Emission Luminogens for Image-Guided Surgery in Non-Human Primates' Nature Communications, 2021, 12, 6485 (IF=17.694) 16. Chen Q,... Zhou M*'Wrapping Porphyromonas gingivalis as 'oncolytic bacteria' for tumor microenvironment immunomodulation and photothermal immunotherapy'Nano Today, 2021, 41, 101311 (IF=18.962)17. Lin X, He J, ... Zhou M* 'Lung targeting protein microspheres for lethal MRSA pneumonia and related biofilms management'ACS Nano, 2021, 150, 16625-16641(IF=18.027)18. Zheng B, Zhong D, Li W, ... Zhou M*'Near-infrared photosensitization via direct triplet energy transfer from lanthanide nanoparticles' Chem, 2021, 7, 1615-1625 (IF=25.832)19. Wei Q, Arami H, ... Zhou M*'Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles' Advanced Sciences, 2021,8, 2002788 (IF=17.521)20. Hua S, Zhong S, ... Zhou M*'Simultaneous Deep tracking of Stem Cells by Surface Raman Enhanced Imaging combined with Single-cell Tracking by NIR-II imaging in Myocardial Infarction' Advanced Functional Materials, 2021, 2100468 (IF=19.924)21. Hua S, He J, ... Zhou M*'Multistage-Responsive Clustered Nanosystem to Improve Tumor Accumulation and Penetration for Photothermal/Enhanced Radiation Synergistic Therapy' Biomaterials, 2021, 268, 120590 (IF=15.304)22. He J, Wei Q, ... Zhou M*'Bioinspired Protein Corona Strategy Enhanced Biocompatibility of Ag-Hybrid Hollow Au Nanoshells for Surface-Enhanced Raman Scattering Imaging and On-Demand Activation Tumor-Phototherapy'Biomaterials, 2021, 271, 120734 (IF=15.304)23. Xie T, Qi Y, ... Zhou M*'Ultrasmall Ga-ICG Nanoparticles Based Gallium Ion/Photodynamic Synergistic Therapy to Eradicate Biofilms and against Drug-Resistant Bacterial Liver Abscess'Bioactive Materials, 2021, 6, 3812 (IF=16.874） 24. Qiao Y, Yang F, Xie T, Du Z, ... Zhou M*'Engineered algae: a novel oxygen-generating system for effective treatment of hypoxic cancer' Science Advances, 2020, 6, eaba5996 (IF=14.957) 25. Zhong D, Li W, Qi Y, He J, Zhou M*'Photosynthetic Biohybrid Nanoswimmers System to Alleviate Tumor Hypoxia for Triple-Modal Imaging-Guided Radio-Photodynamic Synergetic Therapy' Advanced Functional Materials, 2020, 30, 1910395 (IF=19.924, Inside Back Cover封面文章)26. Qiao Y, He J, Chen W, … Zhou M*'Light-Activatable Synergistic Therapy of Drug-Resistant Bacteria Infected Cutaneous Chronic Wound and Non-Healing Keratitis by Cupriferous Hollow Nanoshells' ACS Nano, 2020, 14, 3299–3315 (IF=18.027, Supplementary Cover封面文章) 27. Li Y, Chen W, Qi Y, … Zhou M*'H2S-Scavenged and Activated Iron Oxide-Hydroxide Nanospindles for MRI-Guided Photothermal Therapy and Ferroptosis in Colon Cancer' Small, 2020, 16, 202001356 (IF=15.153) 28. Zhong D, Zhang D, Xie T, Zhou M*'Biodegradable Microalgae-based Carriers for Targeted Delivery and Imaging-guided Therapy toward Lung Metastasis of Breast Cancer' Small, 2020, 16, 202000819 (IF=15.153, Inside Front Cover 封面文章) 29. He J, Qiao Y, Zhang H, … Zhou M*'Gold-Silver Nanoshells Promote Wound Healing from Drug-Resistant Bacteria Infection and Enable Monitoring via Surface-Enhanced Raman Scattering Imaging' Biomaterials, 2020, 119763 (IF=15.304). 30. Li Y, Qi Y, Zhang H, ... Zhou M*'Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostic'Biomaterials, 2020, 226, 119538 (IF=15.304）31. Zhong D, Zhao J, Li Y, ... Zhou M* 'Laser-Triggered Aggregated Cubic α-Fe2O3@Au Nanocomposites for Magnetic Resonance Imaging and Photothermal/Enhanced Radiation Synergistic Therapy' Biomaterials, 2019, 219, 119369 (IF=15.304） 32. Qiao Y, Ping Y, Zhang H, ... Zhou M*'Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds' ACS Applied Materials & Interfaces, 2019, 11, 3809-3822 (IF=10.383) 33. Ji J, Ma F, Zhang H, … Zhou M*'Light-Activatable Assembled Nanoparticles to Improve Tumor-Penetration and Eradicate Metastasis in Triple Negative Breast Cancer' Advanced Functional Materials, 2018, 201801738, 1-14 (IF=19.924, Front Cover封面文章) 34. Wei Q, Chen Y, Ma X, … Zhou M*'High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy' Advanced Functional Materials, 2018, 28, 1704634, 1-12 (IF=19.924, Back Cover封面文章) ESI 高被引论文 35. Qiao Y, Ma F, Liu C, … Zhou M*'Near-Infrared Laser-Excited Nanoparticles to Eradicate Multidrug-Resistant Bacteria and Promote Wound Healing’ ACS Applied Materials & Interfaces, 2018, 10, 193-206 (IF=10.383) 36. Li Y, Wei Q, Ma F, ... Zhou M*'Surface-enhanced Raman nanoparticles for tumor theranostics applications’ Acta Pharmaceutica Sinica B. 2018, 8, 349-359（IF=14.903)工作招聘、研究生招生及培养 2023年计划招收1-2名优秀的博士毕业生(分子生物学、药学、材料学、化学、医学等领域)到本实验室进行博士后研究，待遇从优！ 热诚欢迎对医学影像学、纳米医学或药学(药剂学或药理学)等前沿研究方向感兴趣的同学报考硕士、博士研究生! 每年计划招收硕博连读或博士研究生1-2名及硕士研究生1-2名，欢迎具有医学、生物学、药学、材料，化学等专业背景的学生报考；特别优秀的研究生将有机会到海外著名学府和科研机构进行联合培养1-2年。课题组成员获得的奖励及项目：1. 博士后： 杜 祯：国家自然科学基金青年项目、中国博士后科学基金特别资助、中国博士后科学基金面上项目、浙江大学-斯坦福大学创新人才博士后项目 陈 琪：中国博士后科学基金特别资助、中国博士后科学基金面上项目、浙江大学-斯坦福大学创新人才博士后项目 曹芷源：中国博士后科学基金特别资助 李杨杨：国家重点研发计划子课题、中国博士后科学基金面上项目（一等） 夏志明：国家重点研发计划子课题 钟丹妮：中国博士后科学基金面上项目（一等）2. 研究生： 钟丹妮：国家奖学金（2次）、浙江省优秀毕业生、浙江大学优秀毕业生、浙江大学2021年度学生十大学术成果奖、恒瑞医学奖学金 魏巧琳：国家奖学金、浙江省优秀毕业生、浙江大学优秀毕业生、庄氏奖学金 乔 越：国家奖学金、浙江省优秀毕业生、浙江大学优秀毕业生、孙宇政奖学金 周 博：国家奖学金、浙江大学优秀毕业生 张东晓：国家奖学金、浙江省优秀毕业生 刘超亿：国家奖学金、浙江大学优秀毕业生 叶 洋：国家奖学金、浙江省优秀毕业生、浙江大学优秀毕业生、中华医学会第二十五届全国眼科学术大会优秀论文奖、全国临床医学博士学术论坛一等奖、浙江大学创新创业奖 胡惠群：国家奖学金、浙江大学全国临床博士生学术论坛二等奖 华诗远：国家奖学金 何 健：王惕悟奖学金 金康裕：浙江省优秀毕业生、浙江大学优秀毕业生 王清雅：浙江大学优秀毕业生 内容来自dedecms
