个人简介 Personal Profile 毕业于上海交通大学医学院，获外科学博士学位。上海市医学会神经外科专业委员会委员；上海市医师协会神经外科专业委员会委员；上海市脑卒中学会理事；中国医师协会显微神经外科疾病专业委员会委员；中国医药卫生文化协会心身医学研究分会常委；中国卒中学会复合介入神经外科分会委员。曾在安徽省立医院神经外科和上海交通大学附属仁济医院神经外科工作学习。2006年在北京宣武医院Yasargil显微神经外科培训班学习，熟练掌握小血管吻合技术。2007年作为访问学者在美国国际著名的脑血管疾病诊治中心St. Jorseph’s医院BNI交流学习，师从国际杰出的神经外科大师Spetzler教授。长期从事神经外科疾病的基础和临床工作，具备娴熟的显微神经外科技术，开展多种颅内和椎管内肿瘤（脑膜瘤、脊膜瘤、神经胶质瘤、听神经瘤、神经鞘瘤、转移瘤、血管母细胞瘤）的显微手术治疗；颅内和椎管内血管病（颅内动脉瘤；脑动静脉畸形；烟雾病、缺血性脑血管；高血压性脑出血、动静脉瘘等）的显微手术；颅神经疾病（三叉神经痛、面肌痉挛、舌咽神经痛等）微血管减压手术；各种重度颅脑损伤的救治等，其中采用改良颅内外血管搭桥治疗颅内闭塞性脑血管病；经侧裂微创手术治疗高血压性脑出血等，以“精准、微创”的临床技术理念，取得了良好的临床效果。承担多项国家自然科学基金项目，在Neurosurgery、JNeurosurg、BrainBehav Immun、Neuroscience、Behav Brain Res、J Inflammtion、Brain Res、Cell Death Dis、J Clin Neurosci、Eur J Neurol、J Neurol Sci、中华神经外科杂志、中华医学杂志（英文版）、中华神经病学杂志等多种国内外专业性权威期刊发表学术论文70余篇，其中SCI收录论文40余篇，曾获教育部自然科学二等奖，授权国家发明专利1项，实用专利1项。 研究方向Research Directions 脑血管病基础与临床 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 团队展示 神经外二科目前有专业医师8人，其中具有博士学位4人，硕士学位4人，博士生导师1名，硕士生导师2名。科室广泛开展颅内和椎管内肿瘤性疾病、血管性疾病、颅神经疾病等显微手术治疗。 项目情况 科室承担多项国家自然科学基金项目。 科研项目 1.国家自然科学基金：基于神经血管单元修复的缓释VEGF/bFGF和血管重建干预慢性缺血性认知障碍的作用及机制研究（81974207），2020-2023，主持，55万元。2.国家自然科学基金：缓释VEGF调控的血管重建协同FAAH抑制剂URB597改善慢性脑缺血性认知障碍的作用研究（81771410），2018-2021，主持，54万元。3.国家自然科学基金：内源性大麻素系统对慢性脑灌注大鼠认知功能的调控作用（81271212），2012-2016，主持，70万元。4.国家自然科学基金：新型AEA类似物对慢性脑低灌注大鼠认知功能的保护作用（81071063），2010-2013，主持，32万元。5.国家自然科学基金：泛素-蛋白酶体途径对慢性脑低灌注大鼠认知功能的影响及机制研究（30772233），2008-2011，主持，29万元。 研究成果 1. Shao-Hua Su, Ming Chen, Yi-FangWu, Qi Lin, Da-Peng Wang, Jun Sun, Jian Hai. Fecal microbiota transplantationand short-chain fatty acids protected against cognitive dysfunction in a ratmodel of chronic cerebral hypoperfusion. CNS Neuroscience& Therapeutics, 2023; 00: 1–17.2. Yi-Fang Wu, Kai-Yan Jin,Da-Peng Wang, Qi Lin, Jun Sun, Shao-Hua Su, Jian Hai. VEGF loaded nanofibermembranes inhibit chronic cerebral hypoperfusion-induced cognitive dysfunctionby promoting HIF-1a/VEGF mediated angiogenesis. Nanomedicine: Nanotechnology,Biology, and Medicine, 2023; 48: 102639. 3. Shao Hua Su, Yi Fang Wu, QiLin, Lin Zhang, Da Peng Wang, Jian Hai. Fecal microbiota transplantation andreplenishment of short chain fatty acids protect against chronic cerebralhypoperfusion induced colonic dysfunction by regulating gut microbiota,differentiation of Th17 cells, and mitochondrial energy metabolism. Journal ofNeuroinflammation, 2022; 19: 313. 4. Da-Peng Wang , Kai Kang , JunSun , Qi Lin, Qiao-Li Lv , Jian Hai. URB597 and Andrographolide Improve BrainMicrovascular Endothelial Cell Permeability and Apoptosis by Reducing OxidativeStress and Inflammation Associated with Activation of Nrf2 Signaling inOxygen-Glucose Deprivation. Oxidative Medicine and Cellular Longevity, Oxid MedCell Longev, 2022; 2022: 41393305. Wang DP,Jin KY, Zhao P, Lin Q, Kang K, Hai J. Neuroprotective effects of VEGF-A nanofibermembrane and FAAH inhibitor URB597 against oxygen–glucose deprivation-induced ischemicneuronal injury. Int J Nanomed, 2021; 16: 3661-3678.6. Wang DP,Lin Q, Kang K, Wu YF, Su SH, Hai J. Preservation of spatial memory and neuroprotectionby the fatty acid amide hydrolase inhibitor URB597 in a rat model of vascular dementia.Ann Transl Med, 2021; 9(3): 228.7. Wang DP,Kang K, Lin Q, Hai. Prognostic significance of preoperative systemic cellular inflammatorymarkers in gliomas: a systematic review and meta-analysis. Clin Transl Sci,2020; 13: 179–188.8. Wang DP,Chen SH, Wang D, Kang K, Wu YF, Su SH, Zhang Y, Hai J. Neuroprotective effectsof andrographolide on chronic cerebral hypoperfusion-induced hippocampalneuronal damage in rats possibly via PTEN/AKT signaling pathway. ActaHistochemica, 2020; 122: 151514.9. Wang DP, LvQL, Lin Q, Kang K, Jin KY, Hai J. The cannabinoid receptor agonist WIN55,212-2 ameliorateshippocampal neuronal damage after chronic cerebral hypoperfusion possibly throughinhibiting oxidative stress and ASK1-p38 signaling. Neurotoxicity Res, 2020;37: 847–856.10. Wang DP,Yin H, Lin Q, Fang SP, Shen JH, Wu YF, Su SH, Hai J. Andrographolide enhanceshippocampal BDNF signaling and suppresses neuronal apoptosis, astroglialactivation, neuroinflammation, and spatial memory deficits in a rat model ofchronic cerebral hypoperfusion. Naunyn-Schmiedeberg's Arch Pharmacol, 2019;392:1277-1284.11. Su SH, WuYF, Lin Q, Wang DP, Hai J. URB597 protects against NLRP3 inflammasomeactivation by inhibiting autophagy dysfunction in a rat model of chroniccerebral hypoperfusion. J Neuroinflammation, 2019; 16:260-275.12. Wang DP, Yin H, Kang K, Lin Q,Su SH, Hai J. The potential protective effects of cannabinoidreceptor agonist WIN55,212-2 on cognitive dysfunction is associated with thesuppression of autophagy and inflammation in an experimental model of vasculardementia. Psychiatry Res, 2018; 267:281–288.13. Su SH, Wu YF, Wang DP, Hai J. Inhibitionof excessive autophagy and mitophagy mediates neuroprotective effects of URB597against chronic cerebral hypoperfusion. Cell Death Dis, 2018; 9: 733-747.14. Su SH, Wu YF, Lin Q, Hai J.Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolaseinhibitor URB597 ameliorate neruoinflammatory responses in chronic cerebralhypoperfusion model by blocking NF-B pathways. Naunyn-Schmiedeberg’s Arch Phamacol, 2017; 390(12): 1189-1200.15. Wang DP, Lin Q, Su SH, Liu KJ,Wu YF, Hai J. URB597 improves cognitiveimpairment induced by chronic cerebral hypoperfusion by inhibitingmTOR-dependent autophagy. Neuroscience, 2017; 344: 293-304.16. Wang DP, Liu KJ, Kasper G, LinQ, Hai J. Inhibitionof SENP3 by URB597 ameliorates neurovascular unit dysfunction in rats withchronic cerebral hypoperfusion. Biomed Pharmacotherpy. 2017; 91: 872-879.17. Su SH, Wang YQ, Wu YF, Wang DP,Lin Q, Hai J. Cannabinoid receptor agoinst WIN55,212-2 andfatty acid amide hydrolase inhibitor URB597 may protect cognitive impairment inrats of chronic cerebral hypoperfusion via PI3K/AKT signaling. Behav Brain Res,2016; 313: 334-344.18. Su SH, Wu YF, Lin Q, Yu F, Hai J. Cannabinoid receptor agonist WIN55,212-2 and fatty acidamide hydrolase inhibitor URB597 suppress chronic cerebralhypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinasesignaling. Neuroscience, 2015; 301: 563-575. 19. Su SH, Xu W, Hai J, Yu F, Wu YF, Liu YG, ZhangL. Cognitive function, depression, anxiety and quality oflife in Chinese patients with untreated unruptured intracranial aneurysms. J Clin Neurosci, 2014; 21(10): 1734-1739.20. Su SH, Xu W, Hai J, Wu YF, Yu F. Effects of statins-use for patientswith aneurysmal subarachnoid hemorrhage: a meta-analysis of randomizedcontrolled trials. Sci Rep, 2014; 4: 4573.21. Su SH, Xu W, Li M, Zhang L, Wu YF, Yu F, Hai J.Elevated C-reactive protein levels may be a predictor ofpersistent unfavourable symptoms in patients with mild traumatic brain injury:a preliminary study. Brain Behav Immun, 2014; 38: 111-117. 22. Su SH, Hai J, Zhang L, Yu F, Wu YF. Assessment of cognitive function in adult patients withhemorrhagic moyamoya disease who received no surgical revascularization. Eur J Neurol, 2013 ; 20(7): 1081-1087. 23. Su SH, Hai J, Zhang L, Wu YF, Yu F. Quality of life and psychological impact in adult patientswith hemorrhagic moyamoya disease who received no surgical revascularization. J Neurol Sci, 2013; 328(1-2): 32-36. 24. Hai J, Lin Q, Wu YF, Huang XS, Zhang GY, Wang F. Effects of N-stearoyl-L-tyrosine onthe hippocampal ubiquitin-proteasome system in rats with chronic cerebralhypoperfusion. Neurol Res, 2013; 35(7): 734-743. 25. Jian H, Yi-Fang W, Qi L, Xiao-Song H, Gui-Yun Z. Cerebral blood flow and metabolicchanges in hippocampal regions of a modified rat model with chronic cerebralhypoperfusion. Acta Neurol Belg, 2013; 113(3): 313-317.26. Hai J, Yu F, Lin Q, Su SH. The changes of signal transduction pathways in hippocampalregions and postsynaptic densities after chronic cerebral hypoperfusion inrats.Brain Res, 2012; 1429: 9-17. 27. Hai J, Zhang L, Wan JF, Su SH, Wang F, ZhangGY. A dural arteriovenous fistula in cavernous sinus developedfrom viral meningitis. Acta Neurol Belg, 2011; 111(2): 146-148.28. Hai J, Lin Q, Su SH, Zhang L, Wan JF, Lu Y. Chronic cerebral hypoperfusion in rats causes proteasomedysfunction and aggregation of ubiquitinated proteins. Brain Res, 2011; 1374: 73-81. 29. Hai J, Su SH, Lin Q, Zhang L, Wan JF, Li H, Chen YY, Lu Y. Cognitive impairment and changes ofneuronal plasticity in rats of chronic cerebral hypoperfusion associated withcerebral arteriovenous malformations. Acta Neurol Belg, 2010; 110(2):180-185.30. Hai J, Zhang L, Wang F, Wan JF, Pan QG. Quality of life with special respectto depression after surgical treatment of hypertensive basal gangliahemorrhage. Neurol India, 2010; 58(1): 74-77.31. Lin Q, Hai J, Yao LY, Lu Y. Neuroprotective effects of NSTyr oncognitive function and neuronal plasticity in rats of chronic cerebralhypoperfusion. Brain Res, 2010; 1325: 183-190.32. Hai J, Wan JF, Lin Q, Wang F, Zhang L, Li H,Zhang L, Chen YY, Lu Y. Cognitive dysfunction induced by chronic cerebralhypoperfusion in a rat model associated with arteriovenous malformations. Brain Res, 2009; 1301: 80-88. 33. Hai J, Deng DF, Chen ZQ, Pan QG. Endovascular embolization of smallruptured intracranial aneurysms using a biplane angiographic system withthree-dimensional rotational digital subtraction angiography. J ClinNeurosci, 2009; 16(8): 1028-1033.34. Hai J, Lin Q, Lu Y. Phosphatidylinositol 3-kinaseactivity is required for the induction of differentiation in C6 glioma cells bypanaxydol. J Clin Neurosci, 2009; 16(3): 444-448. 35. Hai J, Lin Q, Zhang H, Lu Y, Yi J. Cyclic AMP-dependent regulation ofdifferentiation of rat C6 glioma cells by panaxydol. Neurol Res,2009; 31(3): 274-279.36. Hai J, Pan QG. Experimentalstudy on the correlation between abnormal muscle responses and F waves inhemifacial spasm. Neurol Res, 2007; 29(6): 553-556.37. Hai J, Lin Q, Lu Y, Yi J, Zhang H. Growth inhibition and induction ofdifferentiation by panaxydol in rat C6 glioma cells. Neurol Res,2008; 30(1): 99-105.38. Hai J, Lin Q, Deng DF, Pan QG, Ding MX. The pre-treatment effect on braininjury during restoration of normal perfusion pressure with hemodilution in anew rat model of chronic cerebral hypoperfusion. Neurol Res, 2007; 29(6):583-587.39. Hai J, Lin Q, Lu Y, Zhang H, Yi J. Induction of apoptosis in rat C6glioma cells by panaxydol. Cell Biol Int, 2007; 31(7): 711-715. 40. Hai J, Chen ZQ, Deng DF, PanQG, Ling F. Recurrentperimedullary arteriovenous fistula at thoracic level. Chin Med J(Engl), 2006; 119(24): 2138-2140. 41. Hai J, Chen ZQ, Deng DF, Pan QG, Ling F. Transvenous treatment of a complexcavernous sinus dural arteriovenous fistula secondary to balloon embolizationof a traumatic carotid-cavernous fistula. Chin Med J (Engl), 2006; 119(21):1846-1848. 42. Hai J, Li ST, Pan QG. Treatment of atypical trigeminalneuralgia with microvascular decompression. Neurol India, 2006; 54(1):53-57.43. Hai J, Lin Q, Li ST, Pan QG. Chronic cerebral hypoperfusion andreperfusion injury of restoration of normal perfusion pressure contributes tothe neuropathological changes in rat brain. Brain Res Mol Brain Res,2004; 126(2): 137-145.44. Hai J, Li ST, Lin Q, Pan QG, Gao F, Ding MX. Vascular endothelial growth factorexpression and angiogenesis induced by chronic cerebral hypoperfusion in ratbrain. Neurosurgery, 2003; 53(4): 963-972.45. Hai J, Ding M, Guo Z, Wang B. A new rat model of chronic cerebralhypoperfusion associated with arteriovenous malformations. JNeurosurg, 2002; 97(5): 1198-1202. 学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份
