个人简介 Personal Profile 夏骁寰，同济大学附属同济医院研究员，博士生导师，上海市麻醉与脑功能调控重点实验室副主任，教育部脑衰老相关疾病医药基础研究创新中心与上海市催化医学前沿科学研究基地骨干科学家。长期致力于神经退行性疾病的发病机制与再生修复方面的研究，重点研究干细胞及其外泌体在神经退行性疾病治疗中的应用前景与作用机制。近五年以第一作者或通讯作者（含共同）身份在Am J Resp Crit Care、Signal Transduct TargetTher（2篇）、Brain Behav Immun、Aging Res Rev、Nano Lett等国际一流学术期刊发表研究论著40余篇，主持国家自然科学基金面上项目（2项）等国家级/省部级课题6项，并担任Transl Neurodegener、Acta Biomaterialia、Medcomm多个期刊客座主编、独立审稿人等工作。 研究方向Research Directions 神经疾病发病机制与治疗策略 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 团队展示 本人于2018年回国加入同济大学郑加麟教授团队，现任同济大学医学院副教授、附属上海市同济医院研究员，带领团队进行神经疾病发病机制与治疗策略研究，所培养的研究生先后荣获博士研究生国家奖学金等荣誉称号，并获得上海市启明星计划扬帆专项、中国博后基金等资助。 项目情况 1. 国家自然科学基金面上项目，82271477，Igf2bp1介导的m6A甲基化异常修饰在阿尔茨海默病神经炎症中的作用及机制研究，2023/01-2026/12。2. 中国卒中学会脑血管病代谢组学青年基金，谷氨酰胺酶介导的小胶质细胞细胞代谢调控在脑卒中神经炎症中的作用及其机制，2023/01-2023/8。3. 同济大学自主原创基础研究项目，22120220596，Igf2bp1介导的m6A甲基化异常修饰在阿尔茨海默病神经炎症中的作用及机制研究，2022/11-2024/10。4. 国家自然科学基金面上项目，81971145，谷氨酰胺酶介导产生的细胞外囊泡在炎症神经突触损伤中的作用及其机制，2020/01-2023/12。5. 国家自然科学基金青年科学基金项目，81901333，诱导性神经干细胞来源外泌体对阿尔茨海默病症状的改善作用及其机制研究，2020/01-2022/12。6. 上海市科技人才扬帆计划项目，19YF1451700，重编程细胞释放的外泌体在神经发生中的作用及其分子机制研究，2019/05-2022/4。7. 中国博士后科学基金面上项目，2018M642087，miR-106b对神经干细胞命运决定的调控及其机制研究，2019/01-2019/12。 研究成果 1. Chen Hǂ, Fu Sǂ, Li Xǂ, Shi Mǂ, Qian J, Zhao S, Yuan P, Ding L, Xia X*,Zheng JC*. Microglial glutaminase 1 mediates chronic restraintstress-induced depression-like behaviors and synaptic damages. SignalTransduct Target Ther. 2023; Accepted. 2. Gao Gǂ, Li Cǂ, Ma Yǂ, Liang Zǂ, Li Y, Li X, Fu S, Wang Y*, Xia X*,Zheng JC*. Neural stem cell-derived extracellular vesiclesmitigate Alzheimer's disease-like phenotypes in a preclinical mouse model. SignalTransduct Target Ther. 2023; 8(1):228. 3. Yuan Pǂ, Bi Yǂ, Luo Yǂ, Tao Q, Gong S, Wang Y, Xiong L*, XiaX*, Zheng JC*. Cognitive dysfunction ofpatients infected with SARS-CoV-2 omicron variant in Shanghai, China.Transl Neurodegener. 2023; 12(1):28. 4. Fu Sǂ, Li Cǂ, Yang W, Chen H, Wang Y, Zhu Y, Zhu J, Zhang B*,Xia X*, Zheng JC*. Insulin-incubatedpalladium clusters alleviate Alzheimer's disease-like phenotypes in apreclinical mouse model. Medcomm. 2023; 4(4):e272. 5. Li X, Zhu Y, Wang Y*, Xia X*, ZhengJC*. Neuralstem/progenitor cell-derived extracellular vesicles: a novel therapy forneurological diseases and beyond. Medcomm.2023; 4(1):e214. 6. Xia Xǂ*, Wang Yǂ, ZhengJC*. Internal m7G methylation:a novel epitranscriptomic contributor in brain development and diseases. Mol Ther-Nucl Acids. 2023; 31:295-308. 7. Yuan Pǂ, Li Jǂ, Liu J, Liu H, Gong S, Wang L, Liu J, Li C, WangY, Xia X*, Zheng JC*. Cognitive dysfunction in patients with pulmonary hypertension. Am J Resp Crit Care. 2022; 206(10):1289-1293. 8. FuSǂ, Chen Hǂ, YangW, Xia X*, Zhao S, Xu X, Ai P, Cai Q, Li X, Wang Y, Zhu J, Zhang B*, Zheng JC*.ROS-targeted depression therapyvia BSA-incubated ceria nanocluster. Nano Letters. 2022; 22(11):4519-4527. 9. Xia X, Wang Y, Qin Y, Zhao S, Zheng JC*. Exosome: a novel neurotransmission modulatoror non-canonical neurotransmitter. AgeingRes Rev. 2022; 74:101558. 10.Xia Xǂ*, Wang Yǂ, Zheng JC*. Extracellularvesicles, from the pathogenesis to the therapy of neurodegenerative disease. Transl Neurodegener. 2022; 11:53.11.Li Yǂ, Xia Xǂ*, Wang Y,Zheng JC*. Mitochondrial Dysfunction in Microglia:A Novel Perspective for Pathogenesis of Alzheimer's Disease. JNeuroinflamm. 2022; 19(1):248.12.FuSǂ, Chen Hǂ,Zhao Sǂ, Yang W, Xia X*, Xu, X, Liang Z, Feng X, Wang Z, Ai P,Ding L, Cai Q, Wang Y, Zhang Y,Zhu J, Zhang B*, Zheng JC*. Insulin-incubated palladium clusterspromote recovery after brain injury. J Nanobiotechnol. 2022; 20:299. 13.Gao Gǂ, Li Cǂ, Zhu Jǂ, Sheng S, Liang Z, Fu S, Li X,Sun Y, Wang Y, Feng X, Xia X*, Zheng JC*. Induced neural stem/progenitorcell-derived extracellular vesicles promote recovery post stroke. Clin Transl Med. 2022; 12(6):e936. 14.Pan Jǂ, Sheng Sǂ, Ye Lǂ, Xu X, MaY, Feng X, Qiu L, Fan Z, Wang Y*, Xia X*, Zheng JC*. Extracellular vesicles derived fromglioblastoma promote proliferation and migration of neural progenitor cells viaPI3K-Akt pathway. Cell. Commun. Signal. 2022; 20(1):7 15.Ding Lǂ, Wu H, WangY, Li Y, Xia X*, Zheng JC*. m6A reader Igf2bp1 regulates theinflammatory responses of microglia by stabilizing Gbp11 and Cp mRNAs.Front. Immunol. 2022; 13:872252. 16.Xia Xǂ*, Wang Yǂ, ZhengJC*. The microRNA-17~92 family as a key regulator of neurogenesisand potential regenerative therapeutics of neurological disorders. Stem Cell Rev Rep.2022; 18(2):401-411 17.Liu Jǂ, Feng Xǂ, Wang Y, XiaX*, Zheng JC*. Astrocytes:GABAceptive and GABAergic cells in the brain. Front Cell Neurosci. 2022; 16:892497. 18.Wang Yǂ, Yuan Pǂ, Ding Lǂ, Zhu J, Qi X, Zhang Y, Li Y*, Xia X*, Zheng JC*. Circulating extracellularvesicle-containing microRNAs reveal potential pathogenesis of Alzheimer'sdisease. Front Cell Neurosci. 2022; 16:955511. 19.Ding Lǂ, Yang Xǂ, Liu Y, Wang Y, Li C, Gao G, Zhao S, Sheng S, Xia X*, Liu J*, Zheng JC*. Exosomes mediate APP dysregulation viaAPP-miR-185-5p axis. Front. Cell Dev.Biol. 2022; 10:793388. 20.Sun Yǂ, Xia Xǂ, Basnet D, Zheng JC*, Huang J*, Liu J*. Mechanisms of ferroptosis and emerging linksto the pathology of neurodegenerative diseases. Front Aging Neurosci. 2022;14:904152. 21.Ding Lǂ, Xu Xǂ, Li Cǂ, Wang Y*, Xia X*, Zheng JC*. Glutaminase in microglia: a novel regulatorof neuroinflammation. Brain Behav Immun. 2021; 92:139-156. 22.Xia Xǂ*, Wang Yǂ, Zheng JC*. COVID-19 andAlzheimer's disease: how one crisis worsens the other. TranslNeurodegener. 2021; 10(1):15. 23.Zhao Sǂ, Sheng Sǂ, Wang Y, Ding L, Xu X, Xia X*, Zheng JC*. Astrocyte-derivedextracellular vesicles: a double-edged sword in central nervous systemdisorders. Neurosci Biobehav Rev. 2021;125:148-159. 24.Xia X*, Yuan P, Liu Y, Wang Y, Cao W, Zheng JC*. Emerging roles of extracellular vesicles in COVID-19,a double-edged sword? Immunology. 2021; 163(4):416-430. 25.Ma Yǂ, Li Cǂ, Xu Xǂ, Wang Y, Huang Y, Zhu J, Xia X*, Zheng JC*. Inducedneural progenitor cell-derived extracellular vesicles promote neural progenitorcell survival via extracellular signal-regulated kinase pathway. CNSNeurosci. Ther. 2021; 27(12):1605-1609.26.LiuJǂ,Ai Pǂ,Sun Yǂ,Yang X, Li C, Liu Y, Xia X*, Zheng JC*. Propofol inhibits microglial activation viamiR-106b/Pi3k/Akt axis. Front.Cell. Neurosci. 2021; 15:768364. 27.Yuan P, Ding L, Chen H, Wang Y, Li C, Zhao S, Yang X, Ma Y, Zhu J, Qi X, Zhang Y, Xia X*, Zheng JC*. Neuralstem cell-derived exosomes regulate neural stem cell differentiation throughmiR-9-Hes1 axis. Front. Cell Dev. Biol. 2021; 9:601600. 28.Xia X, Teotia P, Patel H, van Hook MJ, Ahmad I*.Chemical Induction of Neurogenic Propertiesin Mammalian Müller glia. Stem Cells. 2021; 39(8):1081-1090.29.Xia Xǂ*, Wang Yǂ, ZhengJC*. Emerging roles of extracellularvesicles in mediating RNA virus infection. Fundamental Research. 2021; 2(1):179-18530.Xia Xǂ, Li Cǂ, Wang Y,Deng X, Ma Y, Ding L, Zheng JC*. Reprogrammedastrocytes display higher neurogenic competence, migration ability and celldeath resistance than reprogrammed fibroblasts. Transl.Neurodegener.2020; 9:6 31.GaoGǂ,Li Cǂ,Zhu Jǂ,Wang Y, Huang Y, Zhao S, Ji C, Li C, Sheng S, Yang X, Ye L, Qi X, Zhang Y, Xia X*, Zheng JC*.Glutaminase 1 regulates neuroinflammationafter cerebral ischemia through enhancing microglial activation and pro-inflammatoryexosome release. Front. Immunol. 2020; 11:161 32.Fu S, Wang Y, Xia X*, Zheng JC*.Exosome engineering: current progress incargo loading and targeted delivery. Nanoimpact. 2020; 20:100261 33.Ma Yǂ, Li Cǂ, Huang Y, Wang Y, Xia X*,Zheng JC*. Exosomes released from neural progenitor cells andinduced neural progenitor cells regulate neurogenesis through miR-21a. Cell. Commun. Signal. 2019; 17:96 34.Xia X, Lu H, LiC, Huang Y, Wang Y, Yang X, Zheng JC*. miR-106b regulates the proliferation and differentiation of neuralstem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis. Stem Cell Res Ther.2019; 23; 10(1):282 35.Xia X, Wang Y,Huang Y, Zhang H, Lu H, Zheng JC*. Exosomal MiRNAs in Central Nervous SystemDiseases: Biomarkers, Pathological Mediators, Protective Factors andTherapeutic Agents. Prog Neurobiol.2019; 183:101694 36.MaYǂ, Wang Kǂ, Pan J, Fan Z, Tian C, Deng X, Ma K, Xia X*, Huang Y*, Zheng JC*. Inducedneural progenitor cells abundantly secrete extracellular vesicles and promotethe proliferation of neural progenitors via extracellular signal–regulatedkinase pathways.Neurobiol. Dis.2019, 124:322-334 37.Gao Gǂ, Zhao Sǂ, Xia Xǂ, Li C, Li C, Ji C, Sheng S, Tang Y, Zhu J, Wang Y*, Huang Y*, Zheng JC*. GlutaminaseC regulates microglia activation and pro-inflammatory exosome release:relevance to the pathogenesis of Alzheimer’s disease. Front. Cell. Neurosci. 2019; 13:264 38.Xia X, Teotia P, Ahmad I*. miR-29c Regulates Neurogliogenesis in theMammalian Retina through REST. Dev. Biol. 2019; 450(2):90-100 39. Ma Kǂ, Deng Xǂ, Xia Xǂ, Fan Z, Qi X, Wang Y, Li Y, Ma Y, Chen Q, Peng H,Ding J, Li C, Huang Y*, Tian C*, Zheng JC*. DirectConversion of Mouse Astrocytes into Neural Progenitor Cells and SpecificLineages of Neurons. Transl. Neurodegener. 2018; 5(7):2940. Xia X, Teotia P, Ahmad I*. Lin28a regulates neurogliogenesis in mammalian retina through the Igfsignaling. Dev. Biol. 2018; 440(2):113‐128 学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份
