鲜跃仲 教授、博导院党委书记 化学与分子工程学院 导航 个人资料 研究方向 开授课程 科研项目 学术成果 荣誉及奖励,个人资料 部门: 化学与分子工程学院 毕业院校: 华东师范大学 学位: 博士 学历: 研究生 邮编: 2000241 联系电话: 021-54340046 传真: 021-54340046 电子邮箱: yzxian@chem.ecnu.edu.cn 办公地址: 化学楼323室 通讯地址: 上海市闵行区东川路500号华东师范大学化学与分子工程学院 教育经历 1991年9月—1995年6月:华东师范大学,化学,学士1995年9月—2000年6月:华东师范大学,分析化学,博士 工作经历 2000年7月—2002年7月:华东师范大学,化学系,讲师2002年8月—2007年11月:华东师范大学,化学系,副教授2007年12月—至今:华东师范大学,化学系&化学与分子工程学院,教授 个人简介 2000年7月博士毕业于华东师范大学后留校任教,2002年任副教授,2007年12月晋升教授,博士生导师。主要从事纳米探针设计与生物成像、生物电分析化学、生物与化学传感等方面的研究工作。在Analytical Chemistry、Advanced Functional Materials、ACS Sensors、Nanoscale、Biosensors & Bioelectronics、ACS Applied Materials & Interfaces等国内外主流学术期刊上发表SCI论文140多篇。入选2009年度教育部新世纪人才、2004年度上海市高校优秀青年教师后备人才及2004年度上海市科委青年科技启明星。获2008年度上海市高校优秀青年教师,2006年度上海市教育发展基金会申银万国奖,2017、2001与2000年上海市科技进步奖获得者。 社会兼职 《化学教学》编委 研究方向 米探针设计与生物成像纳米生物分析化学生物电分析化学欢迎报考课题组硕士及博士研究生 开授课程 本科生课程:《分析科学与分析技术》(II)研究生课程:《近代电分析化学》 科研项目 上海市自然科学基金项目:过渡金属二硫属化合物量子点的可控合成、光学性能调控与生物分析应用研究(18ZR1411300),主持国家重点研发计划:资源类及高值产品产地溯源、掺假识别技术研究(2018YFF0215400),参与国家自然科学基金面上项目:基于链接化学策略的石墨烯多功能化、多维成像及分子识别(21175046),主持新世纪人才计划:基于链接化学的纳米微粒多功能化、生物靶向与分子识别性能研究(NCET-09-0357),主持上海市青年科技启明星计划(跟踪):基于链接化学的双功能化纳米微粒的合成及其应用研究(09QH1400800),主持国家自然科学基金面上项目:基于链接化学的界面生物功能化及其电化学识别研究(20875031),主持上海市青年科技启明星计划:纳米界面上的生物分子电化学识别研究(04QMX1421),主持国家自然科学基金青年基金项目:纳米材料的功能化设计及其用于生物分子识别检测的电化学研究(20305007),主持 学术成果 代表性论文 (# Co-first Author, * Corresponding Author)DNA gate-based CRISPR-Cas exponential amplification system for ultrasensitive small extracellular vesicle detection to enhance breast cancer diagnosisTan, Wenqiao; Zhang, Cuiling*; Cheng, Shasha; Hu, Xinyu; Wang, Man; Xian, Yuezhong*Analytical Chemistry, 2024, 9, 1328-1335. NIR light-controlled DNA nanodevice for amplified mRNA imaging and precise gene therapyXiang, Miaomiao#; Jiang, Yuelin#; Zhou, Jiajia; Bao, Guochen; Luo, Xianzhu; Zhang, Le; Jin, Dayong; Xian, Yuezhong*; Zhang, Cuiling*Nano Today, 2024, 54, 102110. A near-infrared light-activated nanoprobe for simultaneous detection of hydrogen polysulfide and sulfur dioxide in myocardial ischemia-reperfusion injuryLuo, Xianzhu; Zhang, Cuiling*; Yue, Chenyang; Jiang, Yuelin; Yang, Fei; Xian, Yuezhong*Chemical Science, 2023, 14, 14290-14301. Recent advances in responsive lanthanide-doped luminescence nanoprobes in the near-infrared-II window (Invited Review)Luo, Xianzhu; Zhang, Cuiling*; Yu, Zihang; Wen, Shihui; Xian, Yuezhong*TrAC Trends in Analytical Chemistry, 2023, 169, 117368. Dye-sensitized rare-earth-dope d nanoprob e for simultaneously enhanced NIR-II imaging and precise treatment of bacterial infectionZhu, Yingxin#; Luo, Xianzhu#; Yu, Zihang; Wen, Shihui; Bao, Guochen; Zhang, Le; Zhang, Cuiling*; Xian, Yuezhong*Acta Biomaterialia, 2023, 170, 532-542. An erythrocyte membrane-camouflaged fluorescent covalent organic framework for starving/nitric oxide/immunotherapy of triple-negative breast cancerYuan, Fang; Zhang, Cuiling*; Luo, Xianzhu; Cheng, Shasha; Zhu, Yingxin; Xian, Yuezhong*Chemical Science, 2023, 14, 14182-14192. Polymerase-driven logic signal amplification for the detection of small extracellular vesicle surface proteins and the identification of breast cancerHu, Xinyu; Cheng, Shasha; Luo, Xianzhu; Xian, Yuezhong*; Zhang, Cuiling*Analytical Chemistry, 2023, 95, 10330-10336. Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injuryYuan, Fang; Zhang, Cuiling*; Luo, Xianzhu; Shen, Xiaokun; Xian, Yuezhong*Chemical Communications, 2023, 59, 5122-5125. Dual-channel fluorescent probe for the detection of peroxynitrite and glutathione in mitochondria: accurate discrimination of inflammatory and progressing tumor cellsLuo, Xianzhu; Zhang, Cuiling*; Yuan, Fang; Cheng, Shasha; Zhu, Yingxin; Xiang, Miaomiao; Hu, Xinyu; Xian, Yuezhong*Analytical Chemistry, 2022, 94, 45, 15790–15800. Cell-Membrane-Anchored Upconversion Nanoprobe for Near-Infrared Light Triggered Cell–Cell InteractionsKong, Yujing; Yuan, Fang; Yang, Fei; Zhang, Cuiling*; Xian, Yuezhong*Analytical Chemistry, 2022, 94, 12024–12032 Ratiometrically pH-Insensitive Upconversion Nanoprobe: Toward Simultaneously Quantifying Organellar Calcium and Chloride and Understanding the Interaction of the Two Ions in Lysosome FunctionDing, Caiping; Cheng, Shasha; Yuan, Fang; Zhang, Cuiling*; Xian, Yuezhong*Analytical Chemistry, 2022, 94, 10813-10823 AIEgen-Based sp2 Carbon-Conjugated Covalent Organic Frameworks with High Stability and Emission for Activatable Imaging and Ferroptosis in Target Tumor CellsYou, Jia; Yuan, Fang; Cheng, Shasha; Kong, Qianqian; Jiang, Yuelin; Luo, Xianzhu; Xian, Yuezhong*; Zhang Cuiling*Chemistry of Materials, 2022, 34, 7078-7089 An Ultrasensitive Strand Displacement Signal Amplification-Assisted Synchronous Fluorescence Assay for Surface Proteins of Small Extracellular Vesicle Analysis and Cancer IdentificationCheng, Shasha; Kong, Qianqian; Hu, Xinyu; Zhang, Cuiling*; Xian, Yuezhong*Analytical Chemistry, 2022, 94, 1085-1091 Rational Synthesis of Imine-Linked Fluorescent Covalent Organic Frameworks with Different pK(a) for pH Sensing In Vitro and In VivoYuan, Fang ; Kong, Yujing ; You, Jia; Zhang, Cuiling*; Xian, Yuezhong*ACS Applied Materials & Interfaces, 2021, 13, 51351-5136 Near-Infrared Light Controllable DNA Walker Driven by Endogenous Adenosine Triphosphate for in Situ Spatiotemporal Imaging of Intracellular MicroRNAYe, Mingqiang; Kong, Yujing; Zhang, Cuiling*; Lv, Yifei; Cheng, Shasha; Hou, Dongyan; Xian, Yuezhong*ACS Nano, 2021, 15, 9, 14253–14262 pH-Sensitive Dye-Based Nanobioplatform for Colorimetric Detection of Heterogeneous Circulating Tumor Cells Wang, Xiuli; Cheng, Shasha; Wang, Xinjun; Wei, Liran; Kong, Qianqian; Ye, Mingqiang; Luo, Xianzhu; Xu, Jiao; Zhang, Cuiling*; Xian, Yuezhong*ACS Sensors, 2021, 6, 5, 1925–1932 Rational Modulation of the Luminescence of Upconversion Nanomaterials with Phycocyanin for the Sensing and Imaging of Myeloperoxidase during an Inflammatory ProcessYou, Yi; Cheng, Shasha; Zhang, Li; Zhu, Yingxin; Zhang, Cuiling;* Xian, Yuezhong*Analytical Chemistry, 2020, 92, 5091-5099 Multivalent Aptamer Functionalized Ag2S Nanodots/Hybrid Cell Membrane-Coated Magnetic Nanobioprobe for the Ultrasensitive Isolation and Detection of Circulating Tumor CellsDing, Caiping; Zhang, Cuiling;* Cheng, Shasha; Xian, Yuezhong*Advanced Functional Materials, 2020, 30, 1909781 Near-Infrared Light-Switched MoS2 Nanoflakes@Gelatin Bioplatform for Capture, Detection, and Nondestructive Release of Circulating Tumor CellsWang, Xiuli; Wang, Xinjun; Cheng, Shasha; Ye, Mingqiang; Zhang, Cuiling;* Xian, Yuezhong*Analytical Chemistry, 2020, 92, 3111-3117 A ratiometric fluorescent assay for the detection and bioimaging of alkaline phosphatase based on near infrared Ag2S quantum dots and calceinCai, Meifang; Ding, Caiping; Wang, Fangfang; Ye, Mingqiang; Zhang, Cuiling;* Xian, Yuezhong*Biosensors & Bioelectronics, 2019, 137, 148-153 Ratiometric Upconversion Luminescence Nanoprobe with Near-Infrared Ag2S Nanodots as the Energy Acceptor for Sensing and Imaging of pH in VivoDing, Caiping; Cheng, Shasha; Zhang, Cuiling;* Xiong, Youran; Ye, Mingqiang; Xian, Yuezhong*Analytical Chemistry, 2019, 91, 7181-7188 Nanoscaled luminescent terbium metal-organic frameworks for measuring and scavenging reactive oxygen species in living cellsLi, Huaping; Cao, Xuanyu; Fei, Xinyu; Zhang, Shiming; Xian, Yuezhong*Journal of Materials Chemistry B, 2019, 7, 3027-3033 Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H2S in living cells and zebrafishWang, Fangfang; Zhang, Cuiling;* Qu, Xuetong; Cheng, Shasha; Xian, Yuezhong*Biosensors & Bioelectronics, 2019, 126, 96-101 Transition metal dichalcogenide quantum dots: synthesis, photoluminescence and biological applications (Invited Review)Cao, Xuanyu; Ding, Caiping; Zhang, Cuiling*; Gu, Wei; Yan, Yinghan; Shi, Xinhao; Xian, Yuezhong*Journal of Materials Chemistry B, 2018, 6, 8011-8036 Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor CellsDing, Caiping; Zhang, Cuiling;* Yin, Xueyang; Cao, Xuanyu; Cai, Meifang; Xian, Yuezhong*Analytical Chemistry, 2018, 90, 6702-6709 Platinum Nanoparticle Encapsulated Metal-Organic Frameworks for Colorimetric Measurement and Facile Removal of Mercury(II)Li, Huaping; Liu, Huifang; Zhang, Jidong; Cheng, Yuxiao; Zhang, Cuiling;* Fei, Xinyu; Xian, Yuezhong*ACS Applied Materials & Interfaces, 2017, 9, 40716-401725 Rare earth ions enhanced near infrared fluorescence of Ag2S quantum dots for the detection of fluoride ions in living cellsDing, Caiping; Cao, Xuanyu; Zhang, Cuiling;* He, Tangrong; Hua, Nan; Xian, Yuezhong*Nanoscale, 2017, 9, 14031-14038 Black Phosphorus Quantum Dots as the Ratiometric Fluorescence Probe for Trace Mercury Ion Detection Based on Inner Filter EffectWei Gu, Xueyu Pei, Yuxiao Cheng, Cuiling Zhang,* Jidong Zhang, Yinghan Yan, Caiping Ding, and Yuezhong Xian*ACS Sensors, 2017, 2, 576−582 Label-free upconversion nanoparticles-based fluorescent probes for sequential sensing of Cu2+, pyrophosphate and alkaline phosphatase activityFangfang Wang, Cuiling Zhang*, Qin Xue, Huaping Li, Yuezhong Xian*Biosensors and Bioelectronics, 2017, 95, 21–26 Highly Fluorescent Polyimide Covalent Organic Nanosheets as Sensing Probes for the Detection of 2,4,6-TrinitrophenolCuiling Zhang, Shiming Zhang, Yinghan Yan, Fei Xia, Anni Huang, and Yuezhong Xian*ACS Appl. Mater. Interfaces, 2017, 9, 13415−13421 Facile synthesis of water-soluble WS2 quantum dots for turn-on fluorescent measurement of lipoic acidYinghan Yan, Cuiling Zhang,* Wei Gu, Caiping Ding, Xinchang Li, and Yuezhong Xian*Journal of Physical Chemistry C, 2016, 120, 12170−12177 One-Step synthesis of water-soluble MoS2 quantum dots via a hydrothermal method as a fluorescent probe for hyaluronidase detectionWei Gu, Yinghan Yan, Cuiling Zhang*, Caiping Ding, and Yuezhong Xian*ACS Applied Materials Interfaces, 2016, 8, 11272–11279. Construction of graphene/Au-Nanoparticles/Cucurbit[7]uril-Based Sensor for Pb2+ SensingXinhao Shi, Wei Gu, Cuiling Zhang, Longyun Zhao, Li Li,* Weidong Peng, Yuezhong Xian*Chemistry-A European Journal, 2016, 22, 5643-5648. A facile and one-step ethanol-thermal synthesis of MoS2 quantum dots for two-photon fluorescence imagingWei Gu, Yinghan Yan, Xuni Cao, Cuiling Zhang*, Caiping Ding, Yuezhong Xian* Journal of Materials Chemistry B, 2016, 4(1), 27-31. Controlled growth cerium oxide nanoparticles on reduced graphene oxide for oxygen catalytic reductionWeidong Peng, Longyun Zhao, Cuiling Zhang*, Yinghan Yan, Yuezhong Xian*Electrochimica Acta, 2016, 191, 669–676. MoS2/Nitrogen-doped graphene as efficient electrocatalyst for oxygen reduction reactionKai Zhao, Wei Gu, Longyun Zhao, Cuiling Zhang*, Weidong Peng, Yuezhong Xian*Electrochimica Acta, 2015, 169, 142-149. A label-free colorimetric sensor for Pb2+ detection based on the acceleration of gold leaching by graphene oxideXinhao Shi, Wei Gu, Cuiling Zhang*, Longyun Zhao, Weidong Peng and Yuezhong Xian*Dalton Transaction, 2015, 44, 4623-4629 Sensitive Pb2+ probe based on the fluorescence quenching by graphene oxide and enhancement of the leaching of gold nanoparticlesXinhao Shi, Wei Gu, Weidong Peng, Bingyu Li, Ningning Chen, Kai Zhao, Yuezhong Xian*ACS Applied Materials & Interfaces, 2014, 6(4), 2567-2574. Enzymatic biosensors based on the use of metal oxide nanoparticles (Invited Review)Xinhao Shi, Wei Gu, Bingyu Li, Ningning Chen, Kai Zhao, Yuezhong Xian*Microchimica Acta, 2014, 181(1-2), 1-22 Graphene based electrochemical biosensor for label-free measurement of the activity and inhibition of protein tyrosine kinaseBingyu Li, Xinhao Shi, Wei Gu, Kai Zhao, Ningning Chen, Yuezhong Xian*Analyst, 2013, 138 (23), 7212-7217 Synthesis of water-soluble magnetic graphene nanocomposies for recyclable removal of heavy metal ionsWenjing Zhang‚ Xinhao Shi‚ Yixuan Zhang‚ Wei Gu‚ Bingyu Li, Yuezhong Xian*Journal of Materials Chemistry A‚ 2013, 1(5), 1745-1753 Bacitracin peptide clicked superparamagnetic iron oxide nanoparticles: synthesis‚ characterization and antibacterial activityWenjing Zhang‚ Xinhao Shi‚ Jing Huang‚ Yixuan Zhang‚ Zirong Wu‚ Yuezhong Xian*ChemPhysChem‚ 2012‚ 13, 3388-3396 A colorimetric sensor based on catechol-terminated mixed self-assembled monolayers modified gold nanoparticles for ultrasensitive detections of copper ionsSiqiu Ye‚ Xinhao Shi‚ Wei Gu‚ Yixuan Zhang, Yuezhong Xian*Analyst‚ 2012, 137 (14), 3365 - 3371 Magnetically controlled bioelectrocatalytic system based on ferrocene-tagged magnetic nanoparticles by thiol-ene reactionCong Liang‚ Li Jing‚ Xinhao Shi‚ Yixuan Zhang‚ Yuezhong Xian* Electrochimica Acta‚ 2012‚ 69: 167-173 Fluorescent probe for Fe(III) based on pyrene grafted multiwalled carbon nanotubes by click reactionLi Jing‚ Cong Liang‚ Xinhao Shi‚ Siqiu Ye‚ Yuezhong Xian*Analyst‚ 2012‚ 137, 1718-1722 Rhodamine-B decorated superparamagnetic iron oxide nanoparticles: preparation‚ characterization and their optical/magnetic propertiesWenjing Zhang‚ Yixuan Zhang‚ Xinhao Shi‚ Cong Liang‚ Yuezhong Xian*Journal of Materials Chemistry‚ 2011‚ 21,16177 - 16183 An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMsYuan Tian‚ Siqiu Ye‚ Xinhao Shi‚‚ Li Jing‚ Cong Liang‚ Yuezhong Xian* Analyst‚ 2011‚ 136 (23)‚ 5084 - 5090 Direct electrochemistry of horseradish peroxidase immobilized on electrografted 4-ethynylphenyl film via click chemistryQin Ran‚ Ru Peng‚ Cong Liang‚ Siqiu Ye‚ Yuezhong Xian∗‚ Wenjing Zhang‚ Litong JinAnalytica Chimica Acta‚2 011‚ 697: 27–31 Magnetically switchable bioelectrocatalytic system based on ferrocene grafted iron oxide nanoparticlesRu Peng‚ Wenjing‚ Zhang‚ Qin Ran‚ Cong Liang‚ Li Jing‚ Siqiu Ye‚ Yuezhong Xian* Langmuir‚ 2011‚ 27‚ 2910-2916 Generation of surface-confined catechol terminated sams via electrochemically triggered Michael addition: characterization‚ electrochemistry and complex with Ni(II) and Cu(II) cationsYuan Tian‚ Siqiu Ye‚ Qin Ran‚ Yuezhong Xian*‚ Jingjing Xu‚ Ru Peng‚ Litong Jin Physical Chemistry Chemical Physics‚ 2010‚ 12‚ 13287-13295. Layer-by-layer assembly of poly(sodium 4-styrenesulfonate) wrapped multiwalled carbon nanotubes with polyaniline nanofibers and its electrochemistryZhichao Hu‚ Jingjing Xu‚ Yuan Tian‚ Ru Peng‚ Yuezhong Xian*‚ Qin Ran‚ Litong JinCarbon‚ 2010‚ 48, 3729-3736. Ferrocene clicked poly(3‚4-ethylenedioxythiophene) conducting polymer: characterization, electrochemical and electrochromic propertiesJingjing Xu‚ Yuan Tian‚ Ru Peng‚ Yuezhong Xian*‚ Qin Ran‚ Litong JinElectrochemistry Communications‚ 2009‚ 11(10), 1972-1975. High-quality covalently grafting hemoglobin on gold electrode: characterization‚ redox thermodynamics and bioelectrocatalysisYuan Tian‚ Qin Ran‚ Jingjing Xu‚ Yuezhong Xian*‚ Ru Peng‚ Litong JinChemPhysChem‚ 2009‚ 10‚ 3105-3111 Layer-by-layer assembly of polyaniline nanofibers/poly(acrylic acid) multilayer film and electrochemical sensingZhichao Hu‚ Jingjing Xu‚ Yuan Tian‚ Ru Peng‚ Yuezhong Xian∗‚ Qin Ran‚ Litong JinElectrochimica Acta‚ 2009‚ 54, 4056–4061 Covalent grafting nitrophenyl group on Au surface via click reaction: assembling process and electrochemical behaviorsLiwei Wang‚ Yuan Tian‚ Qin Ran‚ Zhichao Hu‚ Jingjing Xu‚ Yuezhong Xian*‚ Ru Peng‚ Litong JinElectrochemistry Communications‚ 2009‚ 11: 339–342 Immobilization of horseradish peroxidase on self-assembled (3-mercaptopropyl)trimethoxysilane film: characterization‚ direct electrochemistry‚ redox thermodynamics and biosensingWu FH‚ Hu ZC‚ Xu JJ‚ Tian Y‚ Wang LW‚ Xian YZ*‚ Jin LT Electrochimica Acta‚ 2008‚ 53, 8238-8244 Direct electrochemistry of horseradish peroxidase on TiO2 nanotube arrays via seeded-growth synthesis Wu FH‚ Xu JJ‚ Tian Y‚ Hu ZC‚ Wang LW‚ Xian YZ*‚ Jin LTBiosensors & Bioelectronics‚ 2008‚ 24, 198-203 Electric field directed layer-by-layer assembly of horseradish peroxidase nanotubes via anodic aluminum oxide template Wu FH‚ Hu ZC‚ Wang LW‚ Xu JJ‚ Xian YZ*‚ Tian Y‚ Jin LTElectrochemistry Communications‚ 2008‚ 10, 630-634 Template synthesis of highly ordered Prussian blue array and its application to the glucose biosensingXian YZ‚ Hu Y‚ Liu F‚ Xian Y‚ Feng LJ‚ Jin LT*Biosensors & Bioelectronics‚ 2007‚ 22, 2827-2833 Nanoelectrode ensembles based on conductive polyaniline/poly(acrylic acid) using porous sol-gel films as templateXian YZ‚ Liu F‚ Feng LJ‚ Wu FH‚ Wang LW‚ Jin LT*Electrochemistry Communications‚ 2007‚ 9, 773-780 Encapsulation hemoglobin in ordered mesoporous silicas: influence factors for immobilization and bioelectrochemistryXian YZ‚ Xian Y‚ Zhou LH‚ Wu FH‚ Ling Y‚ Jin LT*Electrochemistry Communications‚ 2007‚ 9, 142-148 Preparation of methylene blue-doped silica nanoparticle and its application to electroanalysis heme proteinsXian YZ‚ Liu F‚ Xian Y‚ Zhou YY‚ Jin LT*Electrochimica Acta‚ 2006‚ 51, 6527-6532 Glucose biosensor based on Au nanoparticles-conductive polyaniline nanocompositeXian YZ‚ Hu Y‚ Liu F‚ Xian Y‚ Wang HT‚ Jin LT*Biosensors & Bioelectronics‚ 2006‚ 21, 1996-2000. Preparation of poly(vinylpyrrolidone)-protected Prussian blue nanoparticles-modified electrode and its electrocatalytic reduction for hemoglobinXian, YZ; Zhou, YY; Xian, Y; Zhou, LH; Wang, HT; Jin, LT*Analytica Chimica Acta, 2005, 546, 139-146 Nanostructured electrode based on multi-wall carbon nanotubes/Pt microparticles nanocomposite for electrochemical determination of thiols in rat striatum by high performance liquid chromatography separationXian, YZ; Zhou, YY; Wang, HT; Zhou, LH; Liu, F; Jin, LT*Journal of Chromatography B, 2005, 817, 239-246 荣誉及奖励 2017年:上海市科技进步奖二等奖2009年:教育部新世纪人才计划2008年:上海市优秀青年教师2006年:申银万国奖2005年:上海市高校优秀青年教师后备人才2004年:上海市青年科技启明星2001年:上海市科技进步奖三等奖2001年:国家“九五”重点科技攻关优秀成果奖2000年:上海市科技进步三等奖 10397 访问 相关教师