导航 个人资料 个人概况 研究方向 开授课程 科研项目 学术成果 荣誉及奖励,高栓虎 个人资料 部门： 高栓虎 化学与分子工程学院 性别： 男 专业技术职务： 教授博士生导师 毕业院校： 兰州大学 学位： 博士 学历： 联系电话： 电子邮箱： shgao@chem.ecnu.edu.cn 办公地址： 化学馆 通讯地址： 上海市 中山北路3663号 邮编： 200062 传真： 工作经历 2010.10－至今：华东师范大学，化学与分子工程学院上海市绿色化学与化工过程绿色化重点实验室上海分子治疗与新药创制工程技术研究中心教授，博士生导师 教育经历 1997.9－2001.7：兰州大学化学化工学院，学士；2001.9－2006.7：兰州大学，功能有机分子国家重点实验室，博士；2006.7－2010.9：美国西南医学中心，博士后； 个人简介 社会兼职 《Organic Chemistry Frontiers》青年编委《有机化学》编委 研究方向 (1) 活性天然产物全合成研究(2) 导向天然产物的合成方法学研究(3) 天然产物药物化学研究 开授课程 研究生专业必修课《有机反应与合成B》 科研项目 1) 国家自然科学基金委员会，杰出青年科学基金，天然产物合成化学, 2023-01-01至2027-12-31；2) 上海市科委基础研究项目，激发态化学反应对映选择性控制研究及合成应用， 2022-07-01至2025-06-303) 国家自然科学基金委员会，面上项目，基于Nazarov反应的活性天然产物合成研究，2022.01至2025.12；4) 国家自然科学基金委员会，面上项目，多环型呫吨酮类天然产物的全合成研究，2020-01至2023-12；5) 上海市科委项目，基于碳氢键活化的化学焊接，2018-06至2021-05,；6) 上海市科委项目，基于不对称光反应的活性天然产物全合成，2018-05至2021-04；7) 国家自然科学基金委员会，面上项目，Gukulenin类天然产物的合成研究，2018-01至2021-12；8) 国家自然科学基金委员会，优秀青年基金项目，天然产物合成研究，2015-01至2017-12，；9) 上海市科委项目，Hamigeran 类天然产物的全合成研究，2014-07至2016-06，；10) 国家自然科学基金委员会，面上项目，Tetramic Acid类天然产物的仿生合成研究，2013-01至2016-12；11) 国家自然科学基金委员会，青年科学基金项目，Variecolin类天然产物的全合成研究，2011-09至2014-08 学术成果 完整学术成果：ORCID 0000-0001-6919-4577代表性学术成果67. Hao Shao, Wenheng Liu, Muhan Liu, Haibing He, Qi-Lin Zhou, Shou-Fei Zhu*, Shuanhu Gao*Asymmetric Synthesis of cyclopamine, a Hedgehog (Hh) Signaling Pathway InhibitorJ. Am. Chem. Soc.2023, 145, 25086–25092. DOI: 10.1021/jacs.3c1036266. Hui Wang, Yi Liu, Hongyuan Zhang, Baochao Yang, Haibing He, and Shuanhu Gao * Asymmetric Total Synthesis of Cephalotaxus Diterpenoids: Cephinoid P, Cephafortoid A, 14-epi-Cephafortoid A and Fortalpinoids M‑N, P J. Am. Chem. Soc. 2023, 145, 16988–16994. DOI: 10.1021/jacs.3c05455 65. Shaolei Ding, Yingbo Shi, Baochao Yang, Min Hou, Haibing He, and Shuanhu Gao* Asymmetric Total Synthesis of Hasubanan Alkaloids: Periglaucines A–C, N,O-dimethyloxostephine and Oxostephabenine Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202214873.64. Yanyu Chen, Zhengyuan Xin, Hui Wang, Haibing He and Shuanhu Gao* Asymmetric total synthesis of norzoanthamine and formal synthesis of zoanthenol Org. Chem. Front. 2023, 10, 651–660.63. Quan Zhang, Haibing He and Shuanhu Gao* Total synthesis of streptovertidione and bioinspired transformation to streptovertidine A and formicapyridine AChem. Commun., 2022, 58, 4239–4242. (This article is part of the themed collection: 2022 Pioneering Investigators)62. Baochao Yang, Guoen Wen, Quan Zhang, Min Hou, Haibing He, Shuanhu Gao* Asymmetric Total Synthesis and Biosynthetic Implications of Per-ovskones, Hydrangenone and Hydrangenone BJ. Am. Chem. Soc. 2021, 143, 6370−6375. 61. Zhengyuan Xin, Hui Wang, Haibing He, Xiaoli Zhao, Shuanhu Gao* Asymmetric Total Synthesis of NorzoanthamineAngew. Chem. Int. Ed. 2021, 60, 12807−12812. 60. Mengmeng Xu,† Min Hou,† Haibing He, Shuanhu Gao* Asymmetric Total Synthesis of Aglacins A, B and E Angew. Chem. Int. Ed. 2021, 60, 16655–16660.59. Kuanwei Chen, Tao Xie, Yanfang Shen, Haibing He, Xiaoli Zhao*, Shuanhu Gao* Calixanthomycin A: Asymmetric Total Synthesis and Structural DeterminationOrg. Lett. 2021, 23, 1769−1774.58. Chaoying Zheng, Tao Xie, Haibing He,* Shuanhu Gao* Asymmetric Total Synthesis of PD-116740 Org. Lett. 2021, 23, 469−473.57. Min Hou, † Mengmeng Xu, † Baochao Yang, Haibing He, Shuanhu Gao* Construction of Polycyclic Structures with Vicinal Quaternary Stereocenters via Enantioselective Photoenolization/Diels–Alder Reaction Chem. Sci. 2021, 12, 7575–7582.56. Xiao-Long Lu,† Yuanyou Qiu,† Baochao Yang, Haibing He, and Shuanhu Gao*Asymmetric Total Synthesis of (+)-Xestoquinone and (+)-Adociaquinones A and BChem. Sci. 2021, 12, 4747–4752.55. Hongyuan Zhang, Haibing He, Shuanhu Gao,*Asymmetric Total Synthesis of Cephanolide A Angew. Chem. Int. Ed. 2020, 59, 20417–20422.54. Delu Jiang, Kunyun Xin, Baochao Yang, Yanyu Chen, Quan Zhang, Haibing He, Shuanhu Gao* Total Synthesis of Three Families of Natural Antibiotics: Anthrabenzoxocinones Fasamycins/naphthacemycins and BenastatinsCCS Chemistry, 2020, 2, 800-812.53. Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma,* Shuanhu Gao,* Xiangbing Qi*An Alkaloid Initiates Phosphodiesterase 3A–Schlafen 12 Dependent Apoptosis without Affecting the Phosphodiesterase Activity, Nature Communications, 2020, 11,3236.52. Yonglei Que, Hao Shao, Haibing He, Shuanhu Gao* Total Synthesis of Farnesin via an Excited-State Nazarov Reaction Angew. Chem. Int. Ed. 2020, 59, 7444-7449. Highlighted by Synfacts. 2020, 16, 498. 51. Tao Xie, Chaoying Zheng, Kuanwei Chen, Haibing He, Shuanhu Gao* Asymmetric Total Synthesis of the Complex Polycyclic Xanthone FD‐594 Angew. Chem. Int. Ed. 2020, 59, 4360-4364. Highlighted by Synfacts. 2020, 16, 374.50. Yang Ji, Zhengyuan Xin, Haibing He, Shuanhu Gao* Total Synthesis of Viridin and Viridiol J. Am. Chem. Soc. 2019, 141, 16208-16212.Highlighted by Synfacts. 2020, 16, 119.49. Jiaxin Zhong, Haibing He,* Shuanhu Gao* Exploration of 1, 3-dipolar Cycloaddition Reaction to Construct the Core Skeleton of Calyciphylline A-type Alkaloids Org. Chem. Front., 2019, 6, 3781-3785.48. Jiaxin Zhong, Kuanwei Chen, Yuanyou Qiu, Haibing He, and Shuanhu Gao* A Unified Strategy To Construct the Tetracyclic Ring of Calyciphylline A Alkaloids: Total Synthesis of Himalensine A Org. Lett. 2019, 21, 3741-3745. 47. Dongsheng Xue, Mengmeng Xu, Chaoying Zheng, Baochao Yang, Min Hou, Haibing He, Shuanhu Gao* Titanium-promoted Intramolecular Photoenolization/Diels–Alder Reaction to Construct Polycyclic Terpenoids: Formal Synthesis of Mycoleptodiscin A Chin. J. Chem. 2019, 37, 135-139.46. Baochao Yang, Shuanhu Gao* Recent Advances in the Application of Diels-Alder Reactions Involving O-quinodimethanes O-quinone Methides and Aza-o-quinone Methides in Natural Products Total Synthesis Chem. Soc. Rev., 2018, 47, 7926-7953.45. Yihua Dai, Feixia Ma, Yanfang Shen, Tao Xie, Shuanhu Gao*Convergent Synthesis of Kibdelone COrg. Lett.2018, 20, 2872–2875.Highlighted by Synfacts. 2018, 14, 784.44. Yuanyou Qiu, Jiaxing Zhong, Shan Du, Shuanhu Gao* Synthetic Studies on Daphniglaucins Chem. Commun., 2018, 54, 5554-5557.43. Yingbo Shi, Yang Ji, Kunyun Xin and Shuanhu Gao* Total synthesis of (−)-Xestosaprol N and O Org. Lett. 2018, 20, 732–735. 42. Yingbo Shi, Haibing He, Shuanhu Gao*Recent Advances in the Total Synthesis of Gracilamine Chem. Commun., 2018, 54, 12905-12913. 41.Yihua Dai, Yanfang Shen, Shuanhu Gao*Cascade Halo-Michael/Aldol Reaction and Its Application in Synthesis Chin. J. Org. Chem. 2018, 38, 1608-1625. 40. Baochao Yang, Shuanhu Gao* The Application of Photochemical Rearrangement of Santonin in Total Synthesis of Complex Natural Terpenoids Acta Chim. Sinica. 2018, 76, 161-167. 39. Yingbo Shi, Qiaoling Wang, Shuanhu Gao*Recent Advances of Using Intramolecular Mannich-reaction in Total synthesis of Alkaloids Org. Chem. Front. 2018, 5, 1049 – 1066. 38. Xiaojun Li, Wanbin Zhang,* Shuanhu Gao* Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies Chin. J. Org. Chem. 2018, 38, 2185-2198.37. Baochao Yang, Kuaikuai Lin, Yingbo Shi, Shuanhu Gao*Ti(Oi-Pr)4-promoted photoenolization Diels–Alder reaction to construct polycyclic rings and its synthetic applicationsNature Communications, 2017, 8, 622.36. Xiaojun Li, Qingfei Zheng, Jun Yin, Wen Liu* and Shuanhu Gao*Chemo-enzymatic Synthesis of EquisetinChem. Commun., 2017, 53, 4695 – 4697.35. Zheming Xiao, Yayue Li, and Shuanhu Gao*Total Synthesis and Structural Determination of the Dimeric Tetrahydroxanthone Ascherxanthone A Org. Lett. 2017, 19, 1834–1837.34. Dan Wang, Min Hou, Yue Ji, and Shuanhu Gao*Total Synthesis of Scholarisine K and Alstolactine AOrg. Lett., 2017, 19, 1922-1925.33. Ke Li, Jinjie Ou, Shuanhu Gao*Total Synthesis of Camptothecin and Related Natural Products by a Flexible StrategyAngew. Chem. Int. Ed. 2016, 55, 14778–14783.32. Xiaojun Li, Dongsheng Xue, Cheng Wang, Shuanhu Gao*Total Synthesis of HamigeransAngew. Chem. Int. Ed. 2016, 55, 9942–9946.31. Yuanyou Qiu and Shuanhu Gao*Trends in Applying C–H Oxidation to Total Synthesis of Natural ProductsNat. Prod. Rep., 2016, 33, 562-581.30. Shuanhu Gao*, Yuanyou QiuAdvances of Radical and Photo Reactions in Natural Products SynthesisSci. Chin. Chem. 2016, 59, 1093-1108. 29. Yingbo Shi and Shuanhu Gao*Recent Advances of Synthesis of Fluorenone and Fluorene Containing Natural ProductsTetrahedron, 2016, 72, 1717-1735.28. Shuanhu Gao,* Advances of Radical and Photo Reactions in Natural Products SynthesisA Photo-induced C-C Bond Formation Methodology to Construct Tetrahydrofluorenones and Related StructuresOrg. Chem. Front. 2016, 3, 354-358.27. Yingbo Shi, Baochao Yang, Shujun Cai, and Shuanhu Gao*Total Synthesis of GracilamineAngew. Chem. Int. Ed. 2014, 53, 9539-9543. Highlighted by Synfacts, 2014, 10, 1011.26. Lili Kong, Mingjin Rao, Jinjie Ou, Jun Yin, Weiqiang Lu, Mingyao Liu, Xiufeng Pang,* and Shuanhu Gao*Total Synthesis and Biological Studies of Cryptocin and Derivatives of Equisetin and Fusarisetin AOrg. Biomol. Chem., 2014, 12, 7591-7597.25. Shujun Cai, Zheming Xiao, Yingbo Shi and Shuanhu Gao*The Photo-Nazarov Reaction: Scope and ApplicationsChem.-Eur. J. 2014, 20, 8677-8681.24. Dan Wang, Shuanhu Gao*Sonogashira Coupling in Natural Product SynthesisOrg. Chem. Front. 2014, 1, 556-566.23. Zheming Xiao, Shujun Cai, Yingbo Shi, Baochao Yang, Shuanhu Gao*Photo-induced C-O Bond Formation to Construct TetrahydroxanthonesChem. Commun. 2014, 50, 5254-5257.(Invited for “2014 Emerging Investigators Issue”)22. Jun, Yin; Gao Shuanhu*Total Synthesis of (+)-Fusarisetin A: A Biomimetic ApproachSynlett. 2014, 25, 1-7.(Invited Synpacts)21. Ke Li, Cheng Wang, Baochao Yang, Shuanhu Gao*Construction of the Basic Skeleton of Ophiobolin A and VariecolinOrg. Biomol. Chem., 2013, 11, 7550-7558.20. Cheng Wang, Dan Wang, and Shuanhu Gao*Total Synthesis of Cyanthiwigins A, C, G and HOrg. Lett. 2013, 15, 4402-4405.19. Jun Yin, Lili Kong, Cheng Wang, YingboShi, Shujun Cai, and Shuanhu Gao*Biomimetic Synthesis of Equisetin and (+)-Fusarisetin AChem.-Eur. J. 2013, 39, 13040-13046.Highlighted in ChemistryViews18. Jun, Yin; Kong, Lili; Gao Shuanhu*Synthetic Progress of FusarisetinAChin. J. Org. Chem.2013, 33, 259-266.17. Jun Yin‚ Cheng Wang‚ LiliKong‚ Shujun Cai‚ Shuanhu Gao*AsymmetricSynthesisand Biosynthetic Implications of (+)-Fusarisetin AAngew. Chem. Int. Ed. 2012‚ 51, 7786-7789.Highlighted in Chemical & Engineering News (JUNE 25, 2012)Highlighted in Organic Chemsitry PortalHighlighted in Chin. J. Org. Chem.Publications during Ph. D. and Postdoctor's research16. Shi, H.; De, S.; Wang, Q.; Shuanhu Gao; Wang, X.; Chuo Chen Construction of the 5,6,7-tricyclic skeleton of lancifodilactone FTetrahedron Lett. 2015, 56, 3225. 15. Zhiqiang Ma†, Xiaolei Wang†, Xiao Wang, Rodrigo A. Rodriguez, Shuanhu Gao,Xianghui Tan, Yuyong Ma, Curtis E. Moore, Arnold L. Rheingold, Phil S. Baran and Chuo ChenAsymmetric syntheses, structural refinement, and biosynthetic implications of sceptrin,massadine, and ageliferinScience, 2014, 346, 219-224.14. Gao Shuanhu; Chen ChuoTotal Synthesis of Natural Products–At the Frontiers of Organic Chemistry;Nakiterpiosin (Chapter 2). Li, J. J., Corey, E. J., Eds.; Springer-Verlag:Berlin/Heidelberg, 2013; 25–38.13. Gao, Shuanhu; Wang, Qiaoling; Wang, Gelin; Lomenick, Brett; Liu, Jie; Fan, Chih-Wei; Deng, Lih-Wen; Huang, Jing; Lum, Lawrence; Chen, ChuoThe Chemistry and Biology of Nakiterpiosin - C-nor-D-HomosteroidsSynlett,2012,23, 2298.12. Shuanhu Gao; Qiaoling Wang; Lawrence Lum; Chuo Chen*.Chemical and Biological Studies of Nakiterpiosin andNakiterpiosinoneJ. Am. Chem. Soc. 2010‚132‚ 371.11. Shuanhu Gao; Qiaoling Wang; Chuo Chen*.Synthesis andStructure Revision of NakiterpiosinJ. Am. Chem. Soc. 2009‚ 131‚ 1410.10. J. R.Falck;* Shuanhu Gao; Ravi Naga Prasad; SreenivasuluReddy Koduru.Electrophilic α-thiocyanation of chiral andachiralN-acyl imides. A convenient route to5-substituted and 5‚5-disubstituted 2‚4-thiazolidinedionesBioorg. Med. Chem. Lett. 2008‚ 18‚ 1768.9. Shuanhu Gao;Yong-Qiang Tu*; Xiangdong Hu; Rongbao Hua; Yijun Jiang; Yuming Zhao;Xiaohui Fan; Shuyu Zhang.General and Efficient Strategy for Erythrinan and Homoerythrinan Alkaloids: Syntheses of(±)-3-demethoxyerythratidinone and (±)-ErysotramidineOrg. Lett. 2006‚ 8‚2373.8. Shuanhu Gao;Yong-QiangTu*; Zhenlei Song; Aixia Wang; Xiaohui Fan; Yijun Jiang.A General and Efficient Strategy for 7-Aryloctahydroindoleandcis-3a-AryloctahydroindoleAlkaloids: Total Syntheses of (±)-γ-Lycorane and(±)-CrinaneJ. Org. Chem. 2005‚ 70‚6523.7. Shuanhu Gao; Yanxing, Jia; Xuezhi Zhao; Yongqiang Tu*A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindonlinesvia AlEt3-promoted TandemReductive Rearrangement of Hydroxy EpoxidesChin. J. Chem. 2006, 24, 595.6. Xiang-Dong Hu; Yong-Qiang Tu*; En Zhang; Shuanhu Gao; Shaohua Wang; Aixia Wang;Chun-An Fan; Min Wang.TotalSynthesis of (±)-GalanthamineOrg. Lett. 2006‚8‚1823.5. Ai-Xia Wang; ZhenLei, Song; Shuanhu Gao; Yi-Jun Jiang; Dao-Yi Yuan; Yong-Qiang Tu; Ning-Zi Li.Studies on Wagner-Meerwein rearrangement of benzospirocyclic β-bromoketones and application to formal synthesis of (±)-ColchicineYouji Huaxue 2007, 27, 1171.4. Ai-Xia Wang; Yong-Qiang Tu; Zhen-Lei Song; Dao-Yi Yuan; Xiang-Dong Hu; Shao-Hua Wang; Shuanhu GaoSynthetically useful Wagner-Meerwein rearrangement of α-quaternary β-bromovinyl methyl ethersEuropean Journal of Organic Chemistry, 2006, 12, 2691.3. Zhenlei Song; Yongqiang Tu; Shuanhu Gao; Yijun Jiang, Shuyu Zhang.Studies on the synthesis of morphinan alkaloid: preparation of the key allylic silyl ether precursorChinese Chemical Letters, 2005, 16, 1445.2. Xue-Zhi Zhao; Lei Peng; Meng Tang; Yong-Qiang Tu; Shuanhu GaoSynthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Precise and Stereocontrolled Synthesis of the Key Mother SpiroketalTetrahedron Lett. 2005, 46, 6941.1. Li, Xin; Wang, Bao-Min; Zhao, Xue-Zhi; Shuanhu Gao; Tu, Yong-Qiang; Li, De-RunExtensive Studies on the AlEt3/THF-Promoted Diastereoselective Tandem Rearrangement Reduction of a-Hydroxy (Amino) Heterocyclopropane: An Efficient Approach to 2-Quaternary 1,3-Diheteroatom UnitsChin. J. Chem. 2004, 22, 1177. 荣誉及奖励 药明康德生命化学研究奖−学者奖（2021）上海市优秀学术带头人（2018）ACP-Lecture Awards (to Hong Kong and Japan)（2016）中国化学会青年化学奖 （2014）Thieme Chemistry Journal Award （2014）
